Ikana Canyon is known to be a cursed land where the Ikana Kingdom once existed, being home to the dead and filled with spirits who linger with regret and hatred. The Garo Ninjas can also be found here spying on the deserted land. Like Great Bay Coast, the Road to Ikana is blocked by fences that can only be jumped over using Epona. To get to Ikana Canyon, Link must show the Garo's Mask or the Gibdo Mask to the Poe Collector. By doing so, the man will make a tree appear beside him, allowing Link to Hookshot up to it and continue on his way. Once further inside the Canyon, Link must make use of his Ice Arrows to cross the Octorok-infested river and Hookshot his way up to the main part of the Ikana Canyon.

Ikana Canyon is notable for having more than twice as many boss battles (mini-boss and optional included) than any other place in the rest of Majora's Mask, totaling twenty-six if each boss is counted as an individual in a battle. During his stay in this region, Link will have to visit most of the landmarks in order to finally bring peace and calm the lingering spirits that fill Ikana Canyon with such a history of greed and hatred.